Commercial Products

Creating the necessary niche for biotechnology R&D in the country, which is one of the main objectives of the Biotechnology Institute, requires diligent work over a long period of time. Scientific research in biotechnology, whose final output consists of applications and products, relies on basic and life sciences. New knowledge paves the way for new products.

Research groups led by Prof. Alp Can and Prof. Aykut Özkul, who have served as director, vice director, and members of the Institute’s founding board, have designed and developed important products related to human and animal health with the help of knowledge made possible by support from the Biotechnology Institute.

Ankara University Biotechnology Institute continues to rely on high quality and competitive scientific research in trying to generate new knowledge and products.

VIRAL DISEASES

The findings of  the research team led by Prof. Aykut Özkul on the prevention and identification of viral diseases are on their way to be transformed into novel products.

Vaccine Development: From Patent to Product

Recombinant virus:

With the projects supported by Ankara University Biotechnology Institute, Ministry of Development and TUBITAK a recombinant Herpesvirus is developped for the first time in Turkey. In this study one of the envelope protein gE of Sığpır Herpesvirus type 1 which can be described as identical to human HSV was knocked out and a recombinant virus was constructed.

The main objective to develop this virus was to determine whether the immune response in the host against this virus that cause infection in 70% of calf population in the country, is because of natural infection or immunization. The engineered virus was tested in parallel with its commercial counterpart in virus sensitive hosts and identical immune response values were obtained. An industrial company proposed to produce this virus as an IBR Marker Vaccine in 2013. The patent application is currently on going. 

OZKUL, A., ALTAS, B., KARAOGLU, T., ALKAN, F., DINCER, E., ONCEL, T., BURGU, I. Maturation Of Immunoglobulin G Avidity After Inactive gE Deleted Bovine Herpesvirus Type 1 (BHV-1) Marker Vaccination. Viral  Immunol, (2008) 21 (1): 3-11.

Diagnostic Systems

1- West Nile Fever Quantitative Real Time RT-PCR (Outside quality validation was successfully done by an international institution)

2- Crimean–Congo hemorrhagic fever Quantitative Real Time RT-PCR

3- PPR Quantitative Real Time RT-PCR

Prof.  Aykut Özkul

REPRODUCTIVE BIOTECHNOLOGY

Today, treatment protocols implemented in assisted reproductive technologies tend to change due to current requirements, in parallel to emerging products and laboratory techniques. Established treatment methods are being reconsidered under the new aspects of current biotechnology.

Biotechnology Institute of Ankara University gives substantial support to investigators studying on this area; therefore productive studies have been employed actively in dedicated laboratories in which primary purpose of researchers is to accomplish a prominent contribution to the field. One of those laboratories is The Reproductive Biology and Stem Cell Laboratories in Department of Histology and Embryology of Ankara University Faculty of Medicine that has been supported since 2001. Investigators under supervision of Prof. Alp CAN, M.D. (Assoc. Prof. Ozgur Cinar, M.D., Sinan Ozkavukcu, M.D., Bio. Deniz Balcı, MSc and Bio. Duru Aras, MSc) continue their studies on new methods and products, which would provide more productive work in reproductive biotechnology and in vitro fertilization (IVF) laboratories and which, in turn, would be useful for patients applying to hospitals with infertility problems. Besides being presented as national/international reports and publications, these studies are also presented to service of end-users in form of commercial products.

TESEperate®

teseparate

One of the most interesting products is TESEparate® (http://www.teseparate.com),a commercially available solution that facilitates to process of testis-originated sperms in the IVF laboratory. The product is a balanced buffer solution functioning based on the principle of removing red blood cells without damaging sperms. Isolating the sperms off the testis biopsies (TESE procedure) becomes much easier with TESEparate® while it also plays a great role in IVF success. This product was introduced to the market as 20 mL solution approximately 1,5 years ago.

 

OvaTrans® ve OvaCryo®

ovatransovacryo

Cryopreservation of cells and tissues, an imperative discipline in biology and cell-tissue science gained extensive interest in recent years. Laboratories mentioned above have performed long-term studies on this area, and projects supported by the Ministry of Industry (SANTEZ) and KOSGEB have been carried out successfully in this context. As a result of those studies, tissue freezing and transfer solutions TissueTrans® and TissueCryo®, and more specifically OvaTrans® and OvaCryo® have been manufactured for proper transfer and freezing of ovary tissue pieces respectively, when fertility preservation is needed.

All the above products are considered as successful examples of university-industry cooperation; as the confirming experiments have been performed in Reproductive Biology and Stem Cell Laboratories partly supported by the Biotechnology Institute and, CE and ISO certificates have been obtained for each product, which have all been introduced to the market recently.

TissueTrans® ve TissueCryo®

TissuetransTissuecryo

Cryopreservation of cells and tissues, an imperative discipline in biology and cell-tissue science gained extensive interest in recent years. Laboratories mentioned above have performed long-term studies on this area, and projects supported by the Ministry of Industry (SANTEZ) and KOSGEB have been carried out successfully in this context. As a result of those studies, tissue freezing and transfer solutions TissueTrans® and TissueCryo®, and more specifically OvaTrans® and OvaCryo® have been manufactured for proper transfer and freezing of ovary tissue pieces respectively, when fertility preservation is needed.

All the above products are considered as successful examples of university-industry cooperation; as the confirming experiments have been performed in Reproductive Biology and Stem Cell Laboratories partly supported by the Biotechnology Institute and, CE and ISO certificates have been obtained for each product, which have all been introduced to the market recently.

NEW!

The current focus of Prof. Alp Can and his team is to develop a new device and a freezing solution for oocyte and embryo cryopreservation. By this project, in which the prototypes are yet to design; approximately 5 million TL-saving per year is targeted.

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